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FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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Symptoms should go away on their own

Topical copper peptides primarily affect the epidermis and upper dermis, where penetration allows direct delivery

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At the same time, CAFs in the tumor microenvironment activate STAT3 signaling by secreting IL-6, promoting the maintenance of stemness and immune escape of resistant clones, driving clonal evolution (Kwon et al., 2025)