tylenol and glutathione depletion Q- Overdose of acetaminophen most likely results in hepatic necrosis due to depletion Acetaminophen causes neurodevelopmental injury in

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A recent study suggests that Bcl-2 regulates mitochondrial GSH content by a direct interaction of the BH3 groove with GSH [132], while the antiapoptotic effect of Bcl-xl has also been attributed to the regulation of GSH homeostasis by preventing GSH loss [133] Figure 5

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