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30 Once the ox-LDL particle has disrupted the integrity of the endothelial barrier, additional LDL particles flood into the arterial wall (intima)

J Immunol (2001) 167:413740

Economies of scale may be limited for peptide drugs treating rare conditions, where small patient populations cannot support large-scale manufacturing investments

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Serotonin receptors are present on peripheral sensory neurons, and serotonergic signaling plays roles in pain modulation and nerve fiber maintenance

They also differ in safety profiles and practical considerations