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In localized radiotherapy, selective lymph node irradiation (which is effective in addressing subclinical lymph node micrometastases) may contribute to an immunosuppressive TME when combined with anti-CTLA-4 antibodies

Together with HDAC13, which dominate chromatin delactylation in cells, sirtuins help maintain lactylation dynamics and substrate selectivity [59]

During embryonic liver development, bone morphogenic protein (BMP), Wnt/-catenin and Notching signaling promote definitive endoderm (DE) formation

Kornblau SM, Womble M, Jackson E, Chen WJ, Estey E, Andreeff M

PMID: 71 LinY.YangJ.LuoL.ZhangX.DengS.ChenX.et al

Uur, ., Tunca, H., Sekmen, E., Neri, ., Aliik, M., Erel, ., & Solmaz, E