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[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Larrey D

Critically, UGT inhibition (not substrate activity) correlates with hepatotoxic potential.A drugs inhibition of UGT enzymes is a direct indicator of increased hepatotoxicity risk

Observed Effects: Any noted changes, both expected and unexpected

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Finally, the enzyme lipoyl transferase 1 catalyzes the transfer of the dihydrolipoyl moiety from the H protein of the glycine cleavage system to conserved lysine residues of the E2 components of the -ketoacid dehydrogenase multienzyme complexes (5)