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measured MMP1, MMP2, TIMP1, and TIMP2 gene expression in human adult dermal fibroblasts exposed to GHK-Cu at 0.01, 1, and 100 nanomolar concentrations and found dose-dependent increases in both MMPs and their inhibitors 11

Furthermore, a chronic inflammatory state in the nervous system intensifies with age, leading to increased microglial activation and elevated levels of proinflammatory cytokines, such as tumor necrosis factoralpha (TNF) and interleukin1 beta (IL1), detectable even preclinically [63, 64]

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Once glutathione molecules reach the gut, they are surrounded by enzymes called gamma-glutamyl transpeptidases, which convert them into relatively ineffective compounds