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High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy

Preclinical research shows an excellent safety profile with no lethal dose identified in animal studies at doses far exceeding human protocols

Marijuana is still a Schedule I substance on the US Controlled Substances Act

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I recommend a consistent weight loss of 1.5 to 2 lbs per week as a target

Data availability The original contributions presented in the study are included in the article/Supplementary Material