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Effect of Ang II on medullary RBF Ang II elicits a paradoxical medullary vasodilatation in normotensive animals, mediated by a secondary activation of vasodilator paracrine agents such as prostaglandins, kinins and NO, rather than to a direct action via AT 2 receptors

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Polymersomes (or polymer vescicles) functionalized with angiopeptide-2 (Ang-2), loaded with gold nanoparticles (AuNPs), and conjugated with doxorubicin (DOX) (Au-DOX@PO-ANG) have demonstrated enhanced permeability across the bloodbrain barrier (BBB) and selective accumulation in malignant brain tissue (61)