AOD9604 has been studied in preclinical and early clinical settings, and it received GRAS (Generally Recognized as Safe) designation from the US FDA for use as a food ingredient
Polyphenols Beyond Barriers: A Glimpse Into the Brain. Current Neuropharmacology 15: 562594
To compare the control group and the group of depressed patients, we used the unpaired Students t-test (normally distributed data) or the Mann-Whitney U test if the data were not normally distributed
According to the IARC, the largest and most important studies consist of combined analyses spanning 17 cohorts from 9 countries in Europe 263 and a multi-cohort study among large cities in the USA 266 , reporting HRs of 1.18 and 1.55 per 5 g/m 3 of PM 2.5 exposure for lung cancer and LUAD, respectively
Conclusions and future perspective Despite a large part of literature exploring on the accumulation and the origin of ROS, current antioxidant-based therapies lack of specificity for dysfunctional tissues, cells, and organelles, and thus may not reach an effective concentration at the target site of pathologic oxidative stress
Most people can be easily treated with injections or tablets to replace the missing vitamins
