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Metformin , the first-line type 2 diabetes drug and an AMPK activator, has cognitive data that are observational and inconsistent, and it lowers BDNF, a growth factor the brain relies on and that exercise raises, which is a reason for caution in a healthy brain

Sermorelin and tesamorelin are GHRH analogs that bind the GHRH receptor, while ipamorelin is a ghrelin mimetic that binds the ghrelin receptor (GHS-R1a)

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Data on full-length thymosin beta-4 do not automatically transfer to the marketed fragment