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Exosomes from Schwann cells attenuate mitochondrial dysfunction and necrotic apoptosis after spinal cord injury via mitophagy mediated by the adenylate-activated protein kinase (AMPK) signaling pathway [108]

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The pleotropic roles of NAD + enable several possible avenues by which repletion of this coenzyme could have therapeutic efficacy

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Freund A, Jolivel V, Durand S, Kersual N, Chalbos D, Chavey C, et al

824 Specifically knockout of NAT10 or inhibiting NAT10 activity in the kidney significantly inhibits ac4C RNA modification and reduces renal I/R injury