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Since B12 is processed in the liver, excessive amounts could potentially lead to complications in severe liver conditions

Jan-Feb 2013;58(1-2):39-46

Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women

These mice were housed at the Laboratory Animal Research Center of the Korea National Institute of Health under controlled conditions: a 16-h light/8-h dark cycle, 23C temperature, and humidity levels of 60 10%

Or weirdly sensitive to everything

Together, they tackle injury from a macro and micro biological level