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Agomelatine (Valdoxan), a synthetic version of the neurohormone melatonin, is approved in Europe as a treatment for depression and has demonstrated anti-anxiety effects

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Anti-estrogen-based endocrine therapies, such as the ER modulator Tamoxifen, ER degrader Fulvestrant, and the aromatase inhibitor Letrozole, have significantly enhanced the survival rates of patients with hormone receptor-positive (HR+) breast cancer [5]

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