2.5 Viral-induced mtDNA release and cross-talk with innate immune signaling pathways Once released into the cytosol, mitochondrial DNA (mtDNA) functions as a potent DAMP that activates multiple innate immune pathways
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Concurrently, dynamin-related protein 1 (Drp1)-mediated excessive fission and impaired PINK1/Parkin-dependent mitophagy exacerbate mitochondrial damage [67, 68], while elevated oxidative stress markers amplify injury
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Furthermore, BV injection has showed an antiapoptotic effect by downregulating Bax and Casp-3 levels ( In addition to the conventional single-variate analysis, we evaluated the effects of BV and GM interventions on the kidney tissue of rats using multivariate statistical analyses
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