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974-977 Esposito, P., et al., 2003

Without standardized formulations and defined perioperative protocols, clinical trials will remain vulnerable to confounding and irreproducibility

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Tri-Luma cream containing hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.1% has been authorized by the FDA for melasma management and should be applied once daily on the affected facial areas for at least 8 weeks (Ferreira Cestari et al., 2007

The NIH 3T3 fibroblast cell viability of the drug loaded core-shell nanofibers was comparable to that in the control (tissue culture polystyrene) implying biocompatibility of the nanofibers and their cell supportive role