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they do not permanently change genetic skin color

Chesser, A

A cofactor is something that is required for an enzyme to catalyze a chemical reaction

Macrophage GSH decreases the cellular oxidative state, the ability of macrophages to oxidize LDL, and the development of atherosclerotic lesions in Apo E-/- mice [161]

LncRNAs, typically exceeding 200 nucleotides, not only regulate gene activity near their synthesis site or at distant locations but also act as sponges to bind miRNAs, thereby inhibiting their ability to regulate other target mRNAs

Exposure to pro-oxidant stimuli usually induces Nrf2 activation and upregulation of antioxidant enzyme expression through binding to the antioxidant response element (ARE), localized in the antioxidant enzyme gene promoters