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CagriSema Combination Dosing When combined with semaglutide, cagrilintide is administered as a fixed-ratio combination [7] : CagriSema 2.4 mg/2.4 mg Cagrilintide: 2.4 mg Semaglutide: 2.4 mg Administered as single weekly injection Separate titration of each component during escalation phase [7] Combination Benefits Single injection improves convenience Fixed ratio ensures consistent synergy Combined titration minimizes side effects 15.6% mean weight loss at 32 weeks [7] Reconstitution and Storage Handling Guidelines for Research Applications Reconstitution Use bacteriostatic water (0.9% benzyl alcohol) for multi-dose vials Sterile water for single-use applications Add solvent slowly down vial wall Gently swirl (do not shake) to dissolve Typical concentration: 1-5 mg/mL Storage Lyophilized powder: Store at -20C, protected from light Reconstituted solution: 2-8C (refrigerate) for up to 28 days with bacteriostatic water Avoid: Freezing reconstituted solution Stability: Peptide is sensitive to heat and light Administration Route and Pharmacokinetics Route: Subcutaneous injection (clinical trials used abdomen, thigh, or upper arm) [2] Absorption: Gradual absorption from subcutaneous depot

10.1182/blood-2008-07-161166 79 MllerC.HardtM.SchwudkeD.NeumanB

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