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This subcluster was predominantly located in severely degenerated cartilage regions and interacted frequently with regenerative clusters (C1-2, C1-4, C2), implying that ferroptotic cells may impair cartilage repair through paracrine effects

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Given that SASP factors influence these(Campisi, 2013), it will be particularly interesting to determine whether FOXO4-DRI affects those p53-wt cancer cells that have adopted a more migratory and stem-like state due to reprogramming by chronic SASP exposure

Authors' contributions PM was responsible for all aspects of the manuscript

Yang Y, Liu Y, Yang Q, Liu T (2024) The application of selenium nanoparticles in immunotherapy