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This occurs in peripheral circulation and can promote symptoms such as postural orthostatic tachycardia syndrome (PoTS), PEM, fatigue, endothelial cell dysfunction, platelet hyperactivation, mast cell activation, and connective tissue disorders

FIG 14A-D Effect of the HGF antagonist Hinge on HGF- and Dihexa-mediated enhancement of mEPSCs in dissociated hippocampal neurons

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As discussed, AD is thought to result from -amyloid (A)-induced proteopathy and immunopathology

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