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Pregnant or breastfeeding women should avoid MOTS-c given the absence of safety data in these populations, as is standard for all investigational peptide therapies

It focuses on gradual escalation of NAD dosage, mimicing cellular adaption, and the oral NR/NMN before the IV phase will help to prep NAD salvage pathways

In a study conducted by Labib et al., four innovative series of tetrazole analogs were developed by bioisosteric substitution of the sulfonamide moiety in celecoxib (Figure 5) with tetrazole, incorporating various core structures such as chalcone, isoxazole, and pyrazole (96)