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Description

Plausible, not proven

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found a significant association between the type 2 ryanodine receptor (RYR2), encoding a stress-induced calcium channel present in many central and peripheral neurons, and CVS [OR = 6.0, (95% CI =1.722)] ( Neuronal Dys-Excitability Disorder Neuronal hyperexcitability may be a common link between CVS and other episodic CNS disorders ( Endocannabinoid System Dysfunction The cannabinoid receptor (CB) 1 and 2, their ligands N-arachidonoylethanolamine (anandamide) and 2- arachidonoylglycerol (2-AG), and their biosynthetic and degradative enzymes are the major components of the endocannabinoid system (ECS) ( Toward a Unifying Hypothesis

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Both amylin and GLP-1 receptor agonists act within this region

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