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When necessary, data were further normalized using MetaboAnalyst 5.0 97,98 , and scaled using GraphPad Prism (version 9.5.1, GraphPad Software)

Direct human oral dose-finding trials are limited

10.1038/msb.2013.31

"Reply to MTHFR C677T and A1298C polymorphisms and mutated sequences occurring in cis"

Various studies have confirmed that the S-Acetyl form is better absorbed through the intestinal wall, as its acetyl bond prevents oxidation and helps the molecule to enter the cells directly after absorption in the intestine