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Early evidence for the potential efficacy of this route was published in 1999, where 18 patients with B12 deficiency treated exclusively with 712 days of 2 mg of sublingual cobalamin daily had 4 times higher B12 levels compared to pre-treatment, reaching therapeutic ranges ( There have also been further studies comparing treatment outcomes from the sublingual route to the more established IM and oral routes

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Cyanocobalamin must convert to this active form before it can be effective

Copper (GHK-Cu) peptide is another peptide that may improve your body's ability to make collagen and elastin, which is a protein in your skin