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What we still do not know Intellectual honesty requires acknowledging the enormous gaps in current evidence

In iron-loaded hepcidin knockout mice, PR65 injections have a milder effect, resulting in partial redistribution of iron from the liver to the spleen

In this study, we examine how diminished GPX4 function may be a critical event in triggering oxytosis/ferroptosis to perpetuate or initiate the neurodegenerative diseases and assess the possible therapeutic importance of oxytosis/ferroptosis in neurodegenerative disorders

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The widely repeated claim that it is ~ten-million-fold more potent than BDNF is a relative in-vitro spine-counting ratio, not a human effect, and key mechanism papers from the originating lab were retracted in 2025