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I.RundleJ.RahmanS.et al (2016)

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In addition, in vitro studies have shown that recombinant TTR amyloid aggregates are internalized by human cardiac fibroblasts, which subsequently secrete IL-6 and IL-8, providing mechanistic evidence that TTR aggregates can trigger inflammatory responses in cardiac cells [77]

Signal Amplification: Activated receptors trigger G-protein coupling, adenylyl cyclase activation, and dramatic increases in intracellular cAMP (often 10-100 fold elevation)

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