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GHSR deficiency exacerbates Parkinsons disease pathology by impairing autophagy

Genomics and transcriptomics describe how genes are regulated and expressed

10.3389/fphar.2021.618411 8 AmandaB

In summary, CDC42, derived from neural stem cell-derived exosomes, as well as TIGAR, FTO, and IRP2, contribute to PD pathology by regulating iron homeostasis, ferroptosis, fatty acid metabolism, the antioxidant system, and angiogenesis

It achieves this at least in part by antagonizing the tumor suppressor functions of the SWI/SNF complex [134], several components of which are AR coregulators [46, 68]

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