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This article extensively outlines the GMs precise regulation of bone metabolic homeostasis, including intestinal barrier homeostasis control, immune homeostasis, the release of metabolic products (e.g., estrogen, IGF-1, and 5-HT signaling), the endocrine system, and the neural circuitry

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This increases the resistance of the mitochondrial network and facilitates complementary interactions between damaged mitochondria (Gan et al., 2018