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The major difficulty in designing effective antioxidants without decomposing the physiological disulfides in biomolecules is that the redox potential of the latter could not so far be determined

However, the effect of C677T polymorphisms of MTHFR on cognitive function was not significant in normal subjects as a longitudinal cognitive study showed that the MTHFR C677T polymorphism was not associated with cognitive performance at baseline or over 12 years 49

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Treatment recommendations are individualized and based on clinical appropriateness rather than a one-size-fits-all approach