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Examples of reactions that can result in product degradation and end of shelf life include Maillard browning (changes in color and flavor), lipid oxidation (rancidity), enzymatic (changes in texture, color, and flavor), and vitamin break down (nutritional quality loss)

In a 9-month monkey oral toxicity study, all female monkeys in the high-dose group showed minimal-to-slight periportal hepatocyte vacuolation