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In phase 1 studies, brensocatib reduced NE levels in blood with acceptable safety and pharmacokinetics (194, 201), prompting a 24-week phase 2 WILLOW trial conducted in 256 patients with bronchiectasis, in which treatment with 10 mg or 25 mg of brensocatib daily for 24 weeks significantly prolonged time to exacerbations compared with placebo (115, 202)
Neuronal cultures pretreated with Dihexa show significantly higher survival rates when exposed to oxidative stress or excitotoxic conditions compared to untreated neurons
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Interestingly, a coronatine-deficient mutant bacterium caused only mild symptoms but consistently induced 2- to 5-times higher GST transcript levels than the coronatine-producing wild type strain
Rapid weight loss disrupts this balance
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