Hoffman-La Roche Ltd Basel, Switzerland This article was underwritten, in part, by a grant from Bayer Consumer Care AG, Basel, Switzerland
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SIRT3 is a histone deacetylase located in the mitochondria that responds to RS and protects cells from genotoxic damage mediated by oxidative processes, thereby reducing cell apoptosis mediated by genotoxins and OS, maintaining mitochondrial homeostasis by deacetylating substrates in an NAD + -dependent manner [143]
Results Impaired epithelial GPX4 activity features CD To investigate a role of reduced GPX4 activity and LPO in human IBD, we analyzed biopsy-derived IEC-enriched specimens from the lesional and non-lesional mucosa of CD and ulcerative colitis (UC) patients with active disease
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