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Prior clinical studies questioned whether older RBCs are equally safe and effective as fresh RBCs, utilizing endpoints such as a multiple organ dysfunction score (MODS) [25], mortality [28] or other combinations of morbidity and mortality [29, 30]

Several hypotheses were made about the health effects of fermented foods such as nutritive alteration of food ingredients and the biosynthesis of different compounds, variations of the gut microbiota, and the immune system modulation [152]