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Ramalho-Santos J, Varum S, Amaral S, Mota PC, Sousa AP, Amaral A

Nature 22 FujiiS.SawaT.IharaH.TongK

Exogenous RONS contributors include air and water pollution, tobacco, alcohol, heavy or transition metals, drugs (e.g., cyclosporine, tacrolimus, gentamicin, and bleomycin), industrial solvents, unhealthy food (e.g., smoked meats, used oils, and fats), radiation, and bacterial, fungal, and viral infections (35, 36)

Administered at a dose of 1200 mg/kg, the treatment significantly downregulated NF-B levels, a key driver of neuroinflammation, showcasing strong anti-apoptotic and anti-inflammatory effects (Qi et al., 2019)

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The level of oxidized glutathione (GSSG) was significantly decreased by 22% after Pycnogenol administration, while reduced glutathione (GSH) was significantly increased by 26.8% after one month and by 36.4% after 2 months compared to baseline (35)