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For oral B12 supplementation with a supplement like Cobalequin, 250 micrograms must be given once daily and continued initially for 12 weeks

Journal of Food Science and Technology

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This often translates into higher energy levels , allowing for more active days and a healthier metabolism overall

However, the intranasal route of drug delivery still has some unresolved issues, such as the need to overcome cilia and mucosal clearance in the vestibular region, as well as enzymatic degradation after the introduction of nanotherapeutic formulations into the nasal cavity[166]