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PINK1 then dimerizes and undergoes autophosphorylation, forming a signaling platform that phosphorylates both ubiquitin and the cytosolic E3 ubiquitin ligase Parkin

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SFs have an intact endogenous dopamine system in which D1R is overexpressed, promoting the migration of RASF cells, leading to a strong increase of SF migration in young patients (146), and decreased release of IL-6 and IL-8

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