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This limitation is shared by most unmodified peptides and is why pharmaceutical peptide drugs require extensive chemical modification or alternative delivery routes

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This effect is partly attributed to the DENV virion or its envelope protein domain III (EIII), a structural component involved in host cell entry

A Novel Microparticle Based Formulation for Topical Delivery of FOL-005, a Small Peptide

Lee, C., Zeng, X., Pulliam, D., Thomson, A., & Cohen, P