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These building blocks can be viewed as forming a pavement ( Figure 4A ), at the bottom of a basin of attraction, in the sense given by Conrad Waddington when describing what he called the epigenetic landscape (323, 324)

Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing

Personal experience, it seems, points to modest, context-dependent effects, rather than dramatic changes

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