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CSCs differ from the adult stem cells in that their division results in tumor initiation and growth [26]

Similarly, HCT116 cells treated with the pan-Raf kinase inhibitor AZ628 (~100-fold higher than the IC 50 ) also yielded a small percentage of DTPs, amounting to ~0.70% of the starting population ( Figures 1B, D, E )

PLoS Negl Trop Dis 8:e3046