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The movement of acylCoA from the cytosol, across the outer mitochondrial membrane, the intermembrane space and the inner mitochondrial membrane and into the mitochondrial matrix is a multistep process facilitated by Lcarnitine and is known as the carnitine shuttle (Figure 1)

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They can become pathologic due to excess production or failure of antioxidant mechanisms [145]

Mechanistically, inhibition of complex I is expected to reduce mitochondrial ubiquinol (CoQ 10 H 2 ) levels, promoting lipid peroxidation and sensitizing cells to ferroptosis 107

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