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The second is the oxidized state (GSSG) , which is what glutathione becomes after it has done its job

Antioxidant Support: Antioxidants like vitamin C and glutathione neutralize free radicals, protecting immune cells from damage and boosting the bodys overall defense mechanisms

In H 2 O 2- induced oxidative stress models in PIG1 and PIG3V cells, vitamin D activated WNT/-Catenin signaling pathway exerted antioxidant activity, the mechanism included the promotion of GSK3 inactivation, increased -catenin nuclear translocation and activation of the downstream Nrf2/ARE pathway

Wang, Z., Petrovic, S., Mann, E

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Source: Phase 2 trial data (Jastreboff et al., NEJM 2023)