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doi: 10.4049/jimmunol.1600242 15 ShevachEM

The way we know its the gut bacteria thats doing it, is that if you give people antibiotics to wipe out gut bacteria, you can apparently eat all the steak you want without making any TMAO

For example, CCL2 secreted by senescent liver cells has been shown to promote the recruitment of bone marrow-derived macrophages, contributing to inflammatory microenvironments (Liu et al., 2024)