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Compared with JAK and TYK2 inhibitors, which exert potent downstream modulation, compounds such as baicalin and EGCG exhibit only partial JAK/STAT or PDE-like immunomodulatory activity, and crucially, they lack human-grade PK/PD validation [36, 37]

Tight junctions transiently loosen, a bit of LPS slips into your bloodstream, and your immune system activates

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Tacrolimus and pimecrolimus are prescription creams that reduce inflammation without the rebound effects of steroids

However, IV administration requires medical supervision and may not be suitable for everyone