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NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular redox reactions and energy metabolism
Digested samples were desalted using a C18 spin column (Pierce C18 Spin, #89873) according to manufacturer instructions prior to resuspension in EPPS buffer and CH 3 CN for TMT labeling as described above
The key context for this comparison is that both compounds are strictly preclinical -- all claims about cognitive effects are based on animal models, and the translation of these findings to human cognition is uncertain
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Most people describe the combined state as 'how my brain is supposed to work', with lasting improvements in how they handle stress even between doses
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