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The dopamine system is similarly regulated by lipid dynamics, with sphingolipids (e.g., ceramide) disrupting the integrity of prefrontal cortical lipid rafts and interfering with the localization of dopamine D1 receptors and cAMP signaling pathways (39)

However, a high incidence of MS has been found in the major medical herb-producing countries, and it is increasing, with many cases in adolescence (Hashem et al., 2010