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Kronqvist, N
Justification for use of FL83B mouse hepatocytes and mouse C2C12 myoblasts Liver is a major player in the synthesis and secretion of VDBP and the hydroxylation of cholecalciferol (vitamin D 3 ) to 25-hydroxy-vitamin D
Stool sample analysis for general HBM studies is typically not conducted, in part because it does not necessarily provide a marker of systemic bioavailability
compatibility should be assessed experimentally Buffer composition, compound sensitivity, and storage duration may influence stability Not suitable for neonatal or in vivo clinical use Intended strictly for laboratory research use References European Pharmacopoeia
People with just one copy of a mutation are said to be heterozygous
The preclinical reports do not resolve that balance for systemic dosing, and no human data address it
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