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Serum concentrations of IGF-2 increase during childhood and then level off at ~500 ng/ml, 29 although abnormal IGF-2 concentrations can occur in certain conditions such as IGF-2-producing tumors
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The translational relevance of these observations to human subjects is unclear since, although men show an age-related decrease in serum ALLO, a similar age-dependent reduction in circulating levels of this neurosteroid is not seen in women (202)
Shared Goal, Different Machinery Because both compounds are studied for the same outcome substantial weight loss it is tempting to treat them as interchangeable
10.1016/j.neuropharm.2011.12.015 186 YamanakaK.BoilleeS.RobertsE
