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Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo

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They are discussed for overlapping reasons, but they come from different biological concepts, are studied through different mechanisms, and raise different safety and regulatory questions

Briefly, L02 cells were transfected with pcDNA3.1(+) or GSTA1 plasmids and incubated for 48 h

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