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ISSN 1083-351X
As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]
Current markers (e.g., GPX4, 4-HNE, and serum iron) lack specificity for ferroptosis-driven RF, as they are also altered in other kidney diseases or metabolic disorders
Przepiorka, D, Ippoliti C, Giralt S, Van Besien K, Mehra R, Deisseroth AB, Andersson B, Luna M, Cork A, Lee M, Estey E, Andreeff M , Champlin R
P : 0.01), and all-cause mortality (HR: 1.52
Nonsegmental vitiligo is the most common type of vitiligo where depigmented patches appear on both sides of the body
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