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Bull Exp Biol Med 2004;137:5102

10.1016/S1470-2045(14)70023-3 Lancet Oncol

Adults usually get 100 to 1,000 mcg of Vitamin B12

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As shown in Figure 3A, reduced expression levels of IL-6 and 8 and MMP3, 12 and 13 were observed in the FOXO4-DRI treated group, which however were concomitantly accompanied with reduced expression of SOX9 and COL2 , as well as increased expression of CDKN2A, CDKN1A , and TP53 (encoding p53)