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Furthermore, in ACLF, sepsis is an important precipitating factor for decompensating liver failure and HE in previously stable patients with cirrhosis [54], indicating the importance of inflammation in the pathogenesis of the disease

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This evidence suggests that CD300ld plays a pivotal role in MDSC-mediated immune suppression, making it an attractive therapeutic target

In a nationwide US cohort with 1,582,914 patients, it was found that there may be a small increase in the risk of developing T2DM in children and adolescents who started SSRI treatment [155]

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